Microwave-assisted Kochetkov amination followed by permanent charge derivatization: a facile strategy for glycomics.
نویسندگان
چکیده
We report a simple and rapid microwave-assisted method for the preparation of oligosaccharide-glycosylamines, followed by labelling with tris(2,4,6-trimethoxyphenyl)phosphonium acetic acid N-hydroxysuccinimide ester. The facile strategy introduced a permanent charge at the reducing end of the oligosaccharide. In combination of MALDI-MS, the detection limit for maltoheptaose was as low as 2 fmol μL(-1).
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 39 شماره
صفحات -
تاریخ انتشار 2010